St. Mary's Hospital is a licensed, 98-acute, 30 skilled nursing bed institution located in Streator, Illinois, approximately 90 miles southwest of Chicago. St. Mary's Hospital is one of 13 affiliates of Hospital Sisters Health System (HSHS), a multi-institutional healthcare system that owns and operates eight hospitals in Illinois and five in Wisconsin.

St. Mary's Hospital is a regional provider for an eight-county area in Central Illinois and one of the largest employers in LaSalle County.

The hospital offers a comprehensive range of healthcare services including: diagnostic imaging, same day surgery, general surgery, obstetrics and gynecology, pediatrics, home health, supportive care, skilled nursing facility, cancer treatment, cardiac rehabilitation, physical and occupational therapies, speech and hearing services, 24-hour emergency services, and ongoing community and patient education.